Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

V Calabrese, A Santoro, D Monti, R Crupi… - Free Radical Biology …, 2018 - Elsevier
In order to better understand the pathogenesis of Parkinson's Disease (PD) it is important to
consider possible contributory factors inherent to the aging process, as age-related changes …

NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols

SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Polyphenols: Major regulators of key components of DNA damage response in cancer

M Majidinia, A Bishayee, B Yousefi - DNA repair, 2019 - Elsevier
DNA fidelity is constantly endangered by various types of intrinsic damages and extrinsic
damages. Cells that are affected by DNA damage employ a specific, intricate, and …

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway

X Chen, M Li, L Li, S Xu, D Huang, M Ju, J Huang… - Scientific reports, 2016 - nature.com
Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in
mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery …

Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis

J Soeur, J Eilstein, G Léreaux, C Jones… - Free Radical Biology and …, 2015 - Elsevier
Skin is particularly exposed to oxidative stress, either from environmental insults such as
sunlight or pollution or as a consequence of specific impairments in antioxidant status …

Modulation of autophagy for controlling immunity

YJ Jang, JH Kim, S Byun - Cells, 2019 - mdpi.com
Autophagy is an essential process that maintains physiological homeostasis by promoting
the transfer of cytoplasmic constituents to autophagolysosomes for degradation. In immune …

Resveratrol: from diet to topical usage

VS Chedea, SI Vicaş, C Sticozzi, F Pessina… - Food & Function, 2017 - pubs.rsc.org
The stilbene derivative resveratrol (3, 5, 4′-trihydroxy-stilbene; RESV) has become the
subject of interest of many researchers and the pharmaceutical industries due to its well …

[HTML][HTML] Effects of Vitis vinifera L. leaves extract on UV radiation damage in human keratinocytes (HaCaT)

L Marabini, G Melzi, F Lolli, M Dell'Agli, S Piazza… - … of Photochemistry and …, 2020 - Elsevier
Vitis vinifera L. water extract from red grapevine leaves contains high levels of polyphenols
in quantities similar to those found in red grape and grape seeds. Phenolic compounds are …

Treatment with maresin 1, a docosahexaenoic acid-derived pro-resolution lipid, protects skin from inflammation and oxidative stress caused by UVB irradiation

TLC Cezar, RM Martinez, C Rocha, CPB Melo… - Scientific reports, 2019 - nature.com
Acute exposure to UVB irradiation causes skin inflammation and oxidative stress, and long-
term exposure to UVB irradiation may lead to carcinogenesis. Our organism has …

A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages

WJ Duan, YF Li, FL Liu, J Deng, YP Wu… - Free Radical Biology …, 2016 - Elsevier
Resveratrol gains a great interest for its strong antioxidant properties, while the molecular
mechanisms underlie the beneficial effects on psychosocial stress remain controversial. In …