Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

Steroids play an important role in the regulation of normal physiology and the treatment of
disease. Steroid receptors have classically been described as ligand-activated transcription …

Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide
(Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological …

Abstract The sphingosine‐1‐phosphate (S1P) family of G protein‐coupled receptors (GPCR)
regulates essential cellular processes such as proliferation, migration, cytoskeletal …

FTY720, a potent immunosuppressive agent, is phosphorylated in vivo into FTY720-P, a
high affinity agonist for sphingosine 1-phosphate (S1P) receptors. The effects of FTY720 on …

Sphingolipid metabolites have emerged as critical players in a number of fundamental
biological processes. Among them, sphingosine-1-phosphate (S1P) promotes cell survival …

Sphingosine-1-phosphate is a bioactive lipid that is mitogenic for human glioma cell lines by
signaling through its G protein-coupled receptors. We investigated the role of sphingosine-1 …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that has been
implicated in many biological processes, including cell migration, survival, proliferation …

Sphingosine 1-phosphate (S1P), a potent sphingolipid mediator produced by sphingosine
kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular processes important for …

Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that promotes cell survival,
proliferation, migration, angiogenesis, lymphangiogenesis, and immune response; all are …