Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

The study of brain connectivity has been a cornerstone in understanding the complexities of
neurological and psychiatric disorders. It has provided invaluable insights into the functional …

Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway
have emerged as major causes of focal malformations of cortical development and …

Epidemiological studies link exposure to viral infection during pregnancy, including
influenza A virus (IAV) infection, with increased incidence of neurodevelopmental disorders …

Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …

Objective Genetic variations in proteins of the mechanistic target of rapamycin (mTOR)
pathway cause a spectrum of neurodevelopmental disorders often associated with brain …

Epilepsy is a multifaceted neurological syndrome characterized by recurrent, spontaneous,
and synchronous seizures. The pathogenesis of epilepsy, known as epileptogenesis …

This review article gives an overview on the molecular, cellular and network mechanisms
underlying focal seizures in neocortical networks with developmental malformations …

Pediatric genetic epilepsies, such as CDKL5 Deficiency Disorder (CDD), are severely
debilitating, with early-onset seizures occurring more than ten times daily in extreme cases …

The lipid storage disease Niemann Pick type C (NPC) causes neurodegeneration owing
primarily to loss of NPC1. Here, we employed a Drosophila model to test links between …