Antibiotics changed medical practice by significantly decreasing the morbidity and mortality
associated with bacterial infection. However, infectious diseases remain the leading cause …

Drug discovery is based on bioactivity screening of natural sources, traditionally represented
by bacteria fungi and plants. Bioactive natural products and their secondary metabolites …

Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

In the last century, life expectancy has increased considerably, thanks to the introduction of
antibiotics, hygiene and vaccines that have contributed to the cure and prevention of many …

The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Antimicrobial resistance is an exigent public health concern owing to the emergence of
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …

Antibiotic resistance is a global problem which affects human health. The imprudent use of
antibiotics (medicine, agriculture, aquaculture, and food industry) has resulted in the broader …

Microbial mats are geobiological multilayered ecosystems that have significant evolutionary
value in understanding the evolution of early life on Earth. Shark Bay, Australia has some of …

Computational methodologies are assisting the exploration of marine natural products
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …

Natural products (NPs) have historically played a primary role in the discovery of small-
molecule drugs. However, due to the advent of other methodologies and the drawbacks of …