Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Covering: 1996–2022 Investigations over the last 2 decades have begun to reveal how
fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Depsides are polyphenolic molecules comprising two or more phenolic acid derivatives
linked by an ester bond, which is called a depside bond in these molecules. Despite more …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and
biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome …

In nature, organic molecules with great structural diversity and complexity are synthesized
by utilizing a relatively small number of starting materials. A synthetic strategy adopted by …

Fusarium mangiferae causes the mango malformation disease (MMD) on young mango
trees and seedlings resulting in economically significant crop losses. In addition, F …

Where does one draw the line between primary and secondary metabolism? The answer
depends on the perspective. Microbial secondary metabolites (SMs) were at first believed …