Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

The lysyl oxidase family comprises five members in mammals, lysyl oxidase (LOX) and four
lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly …

The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

Myeloproliferative neoplasms are associated with increased risk for thrombotic
complications. These conditions most commonly involve somatic mutations in genes that …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which
catalyze cross-linking reactions of elastin and collagen in the connective tissue. These …