Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense.
However, the matrix of interactions between arrays of molecularly defined neuron subsets …

Lipid metabolism plays a major role in the regulation of the immune system. Exogenous
(dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct …

The gastrointestinal tract is home to the largest microbial population in the human body. The
gut microbiota plays significant roles in the development of the gut immune system and has …

The intricate interplay between gut microbes and the onset of experimental autoimmune
encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable …

The last decade of microbiome research has highlighted its fundamental role in systemic
immune and metabolic homeostasis. The microbiome plays a prominent role during …

The intestinal microbiota determines immune responses against extraintestinal antigens,
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …

The incomplete removal of T cells that are reactive against self-proteins during their
differentiation in the thymus requires mechanisms of tolerance that prevent their effector …

Recent strategies to combine chemoradiation with immunotherapy to treat locally advanced
lung cancer have improved five-year survival outcomes. However, collateral toxicity to …