Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

[HTML][HTML] Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Sarcopenia: etiology, nutritional approaches, and miRNAs

R Cannataro, L Carbone, JL Petro, E Cione… - International journal of …, 2021 - mdpi.com
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …

[HTML][HTML] Hallmarks of aging in the liver

NJ Hunt, SWS Kang, GP Lockwood… - Computational and …, 2019 - Elsevier
While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

[HTML][HTML] Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: implications for age-related …

MC Marazita, A Dugour, MD Marquioni-Ramella… - Redox biology, 2016 - Elsevier
Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration
(AMD), a multifactorial disease that includes age, gene variants of complement regulatory …

Inflamm‐aging: a new mechanism affecting premature ovarian insufficiency

Y Huang, C Hu, H Ye, R Luo, X Fu, X Li… - Journal of …, 2019 - Wiley Online Library
The normal function of ovaries, along with the secretion of sex hormones, is among the most
important endocrine factors that maintain the female sexual characteristics and promote …

Bioorthogonal masked acylating agents for proximity-dependent RNA labelling

S Pani, T Qiu, K Kentala, SA Azizi, BC Dickinson - Nature Chemistry, 2024 - nature.com
RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …

Non-coding RNA: role in gestational diabetes pathophysiology and complications

T Filardi, G Catanzaro, S Mardente, A Zicari… - International Journal of …, 2020 - mdpi.com
Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the
second or third trimester of pregnancy. GDM can lead to short-term and long-term …