The re-emergence of natural products for drug discovery in the genomics era
AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery
Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …
products, particularly in the field of drug discovery. While microbes have been shown to …
Integrated omics analysis of specialized metabolism in medicinal plants
Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …
pharmacological properties. Until recently, plant biologists were limited in their ability to …
Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects
Covering: 2000 to 2014 Plant metabolomics has matured and modern plant metabolomics
has accelerated gene discoveries and the elucidation of a variety of plant natural product …
has accelerated gene discoveries and the elucidation of a variety of plant natural product …
Marine microorganisms as a promising and sustainable source of bioactive molecules
There is an urgent need to discover new drug entities due to the increased incidence of
severe diseases as cancer and neurodegenerative pathologies, and reducing efficacy of …
severe diseases as cancer and neurodegenerative pathologies, and reducing efficacy of …
21st century natural product research and drug development and traditional medicines
Covering: 1987 to 2013 Natural products and related structures are essential sources of new
pharmaceuticals, because of the immense variety of functionally relevant secondary …
pharmaceuticals, because of the immense variety of functionally relevant secondary …
Advantages and pitfalls of mass spectrometry based metabolome profiling in systems biology
I Aretz, D Meierhofer - International journal of molecular sciences, 2016 - mdpi.com
Mass spectrometry-based metabolome profiling became the method of choice in systems
biology approaches and aims to enhance biological understanding of complex biological …
biology approaches and aims to enhance biological understanding of complex biological …
Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …
the number of new drugs approved or translated to clinical use raises the question, whether …
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Covering: 2000 to 2016 The labor-intensive process of microbial natural product discovery is
contingent upon identifying discrete secondary metabolites of interest within complex …
contingent upon identifying discrete secondary metabolites of interest within complex …
Biosynthesis of terpenoid natural products in fungi
C Schmidt-Dannert - Biotechnology of isoprenoids, 2015 - Springer
<? xm-replace_text {Heading}?> Abstract Tens of thousands of terpenoid natural products
have been isolated from plants and microbial sources. Higher fungi (Ascomycota and …
have been isolated from plants and microbial sources. Higher fungi (Ascomycota and …