Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

Background Aging decreases skeletal muscle mass and quality. Maintenance of healthy
muscle is regulated by a balance between protein and organellar synthesis and their …

Neurodegenerative diseases are inseparably linked with aging and increase as life
expectancy extends. There are common dysfunctions in various cellular events shared …

Sarcopenia is the loss of both muscle mass and function with age. Although the molecular
underpinnings of sarcopenia are not fully understood, numerous pathways are implicated …

Mechanical perturbation triggers activation of resident myogenic stem cells to enter the cell
cycle through a cascade of events including hepatocyte growth factor (HGF) release from its …

Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for
selective autophagy primarily due to its direct interaction with the microtubule light chain 3 …

Background Alcohol-associated liver disease (ALD) is a worldwide health problem, of which
the effective treatment is still lacking. Both detrimental and protective roles of adipose tissue …

Autophagy is a crucial cell survival mechanism that involves the degradation and recycling
of old or damaged organelles and proteins to maintain cellular homeostasis. Impairments in …