Global plant stress signaling: reactive oxygen species at the cross-road

N Sewelam, K Kazan, PM Schenk - Frontiers in plant science, 2016 - frontiersin.org
Current technologies have changed biology into a data-intensive field and significantly
increased our understanding of signal transduction pathways in plants. However, global …

Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Trial Watch: Toll-like receptor agonists for cancer therapy

E Vacchelli, A Eggermont, C Sautès-Fridman… - …, 2013 - Taylor & Francis
Toll-like receptors (TLRs) have long been known for their ability to initiate innate immune
responses upon exposure to conserved microbial components such as lipopolysaccharide …

Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy

F Aranda, E Vacchelli, A Eggermont, J Galon… - …, 2014 - Taylor & Francis
Immunostimulatory monoclonal antibodies (mAbs) exert antineoplastic effects by eliciting a
novel or reinstating a pre-existing antitumor immune response. Most often …

Trial watch: Chemotherapy with immunogenic cell death inducers

E Vacchelli, L Senovilla, A Eggermont… - …, 2013 - Taylor & Francis
It is now clear that the immune system plays a critical role not only during oncogenesis and
tumor progression, but also as established neoplastic lesions respond to therapy. Selected …

Involvement of Toll-like Receptor 9 polymorphism in cervical cancer development

A Roszak, M Lianeri, A Sowińska… - Molecular biology …, 2012 - Springer
The role played by the polymorphism located in Toll-like Receptor 9 (TLR9) as a risk factor
of cervical cancer remains elusive. Therefore, we studied the association of the TLR9− 1486 …

Trial Watch: Toll-like receptor agonists in oncological indications

F Aranda, E Vacchelli, F Obrist, A Eggermont… - …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are an evolutionarily conserved group of enzymatically inactive,
single membrane-spanning proteins that recognize a wide panel of exogenous and …

Toll-like receptors and human disease: lessons from single nucleotide polymorphisms

YT Lin, A Verma, CP Hodgkinson - Current genomics, 2012 - ingentaconnect.com
Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-
associated molecular patterns, are critical for the normal function of the innate immune …

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis

A Jabłońska, M Studzińska, L Szenborn… - Scientific reports, 2020 - nature.com
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and activate
innate and adaptive immune responses. Single nucleotide polymorphisms (SNPs) within the …

TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants

E Paradowska, A Jabłońska, M Studzińska… - PLoS …, 2016 - journals.plos.org
Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves
as a pattern recognition receptor that signals the presence of human cytomegalovirus …