Bacteria have acquired sophisticated mechanisms for assembling and disassembling
polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α …

Cryo-electron microscopy (cryoEM) has become a well established technique with the
potential to produce structures of large and dynamic supramolecular complexes that are not …

Posttranslational modifications, such as N ε-lysine acetylation, regulate protein function. N ε-
lysine acetylation can occur either nonenzymatically or enzymatically. The nonenzymatic …

Recent studies have drawn attention to the evolution of protein dynamics, in addition to
sequence and structure, based on the premise structure-encodes-dynamics-encodes …

Accurate modeling of structural dynamics of proteins and their differentiation across different
species can help us understand generic mechanisms of function shared by family members …

Proteins are intrinsically flexible macromolecules that undergo internal motions with time
scales spanning femtoseconds to milliseconds. These fluctuations are implicated in the …

Rare codon in a heterologous gene may cause premature termination of protein synthesis,
misincorporation of amino acids, and/or slow translation of mRNA, decreasing the …

We report here on the salient role of protein mobility in accessing conformational
landscapes that enable efficient enzyme catalysis. We are focused on yeast enolase, a …

Highlights•Intrinsic flexibility of proteins is more conserved than structure and
sequence.•Protein flexibility can be derived from coarse-grained elastic network …

Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes from Gram-positive
bacteria are secreted virulence factors that aid in downregulating host immunity. These PI …