The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Stroke continues to be one of the leading causes of mortality and morbidity worldwide.
Restoration of cerebral blood flow by recombinant plasminogen activator (rtPA) with or …

Background Prourokinase is a single-chain plasminogen activator presenting with fewer
hemorrhagic complications and reduced reocclusion rate compared with the conventional …

Importance Recombinant human prourokinase (rhPro-UK) is a thrombolytic agent that has
shown promising findings in a phase 2 clinical trial in patients with acute ischemic stroke …

OBJECTIVE: Intracoronary injection of pro-urokinase (Pro-UK) during percutaneous
coronary intervention (PCI) seems to be a promising treatment in improving myocardial …

Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to
neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We …

Abstract C1 esterase inhibitor (C1INH) is known to exert its inhibitory effect by binding to
several target proteases of the contact and complement systems. One of C1INH's targets …

Results of thrombolysis by monotherapy with either tPA or proUK have not lived up to
expectations. Since these natural activators are inherently complementary, this property can …

One major aim in quantitative and translational neuroscience is to achieve a precise and fast
neuronal counting method to work on high throughput scale to obtain reliable results. Here …

Chronic kidney disease (CKD) is characterised by the pathological accumulation of
extracellular matrix (ECM) proteins leading to progressive kidney scarring via glomerular …