Despite the enormous efforts to elucidate the mechanisms of the development of multiple
organ failure (MOF) following trauma, MOF following trauma is still a leading cause of late …

Trauma represents the leading cause of death among young people in industrialized
countries. Recent clinical and experimental studies have brought increasing evidence for …

Trauma induces a profound immunological dysfunction. This is characterised by an early
state of hyperinflammation, followed by a phase of immunosuppression with increased …

Endothelial wound-healing processes are fundamental for the maintenance and restoration
of the circulatory system and are greatly affected by the factors present in the blood. We …

An in vitro zymosan-activation of the Complement system, through the lectin and alternative
pathways, was performed in pooled human serum over a 24 h time-course. Activation was …

Purpose: The management of burn patients is always challenging for the clinician due to
high risk of bacterial sepsis, multi-organ failure and death. Our objective was to study …

Background Complement activation is a central mechanism in systemic inflammation and
remote organ dysfunction following major trauma. Data on temporal changes of complement …

Progress in resuscitation, damage control, and critical care techniques in the last 50 years
have decreased mortality of trauma patients, enabling severely ill patient to survive the early …

Tissue trauma induces an inflammatory response in the host. Although the inflammatory
response has beneficial effects at the site of injury including wound healing and the …

Das Polytrauma stellt eine häufige Todesursache bei Erwachsenen dar. Posttraumatisch
kann eine starke, systemische Entzündungsreaktion mit Komplementaktivierung zu weiteren …