Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

Recent studies provide increasing evidence that postnatal neovascularization involves bone
marrow–derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Hyperpolarization‐activated cation currents (Ih) have been identified in cardiac pacemaker
cells and a variety of central and peripheral neurons. Four members of a gene family …

The molecular basis of the hyperpolarization‐activated cation channels that underlie the
anomalous rectifying current variously termed Ih, Iq, or If is discussed. On the basis of the …

Mathematical models were developed to reconstruct the action potentials (AP) recorded in
epicardial and endocardial myocytes isolated from the adult rat left ventricle. The main goal …

Objective: A calcium-activated nonselective cation channel (NSCCa) has been recently
described in several cardiac preparations. This channel is over-expressed in models of …

Ventricular pacemaker current (I f) shows distinct voltage dependence as a function of age,
activating outside the physiological range in normal adult ventricle, but less negatively in …

Knowledge of the initiation of electrical and contractile activity in the embryonic heart relies
to a large extent on data obtained in chicken. In recent years, molecular biological …