Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …

Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …

In all the eukaryotic cells, nucleolytic processing (resection) of a double strand DNA break
(DSB) is a key step to channel the repair of the lesion toward the homologous …

The response to a DNA double-stranded break in mammalian cells is a process of sensing
and signalling the lesion. It results in halting the cell cycle and local transcription and in the …

Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

Genomic DNA is damaged at an extremely high frequency by both endogenous and
environmental factors. An improper response to DNA damage can lead to genome …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms:
non-homologous end-joining and homologous recombination. The decision between them …