Decades of work on the spatiotemporal organization of mammalian DNA replication timing
(RT) continues to unveil novel correlations with aspects of transcription and chromatin …

DNA replication ensures the precise transmission of genetic information from parent to
daughter cells. In eukaryotes, this process involves the replication of every base pair within a …

In mammalian cells, chromosomal replication starts at thousands of origins at which
replisomes are assembled. Replicative stress triggers additional initiation events from …

Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our
understanding of the interplay between genetic and epigenetic factors in this regulation …

The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …

Eukaryotic DNA replication is a tightly controlled process that occurs in two main steps, ie,
licensing and firing, which take place in the G1 and S phases of the cell cycle, respectively …

In vertebrates, single cell analyses of replication timing patterns brought to light a very well
controlled program suggesting a tight regulation on initiation sites. Mapping of replication …

During S-phase, the mammalian genome replicates in a defined temporal order called the
DNA Replication Timing (RT) program. This program is developmentally regulated and is …

Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our
understanding of the interplay between genetic and epigenetic factors in this regulation …

This work examines the debate between the luck and relational egalitarians. The former,
including authors like Dworkin, Cohen, Arneson, Tan, and Lippert-Rasmussen, are said to …