Glaucoma, a neurodegenerative disorder that leads to irreversible blindness, remains a
challenge because of its complex nature. MicroRNAs (miRNAs) are crucial regulators of …

Glaucoma is the leading cause of global irreversible blindness, necessitating research for
new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells …

The conventional outflow pathway is a complex tissue responsible for maintaining
intraocular pressure (IOP) homeostasis. The coordinated effort of multiple cells with differing …

Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …

To establish appropriate ex vivo models for a glaucomatous trabecular meshwork (TM), two-
dimensional (2D) and three-dimensional (3D) cultures of human trabecular meshwork cells …

Key points Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that
regulates intraocular pressure through the control of aqueous humour drainage. Its …

High intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of
irreversible blindness. Abnormal fibrotic activity in the human trabecular meshwork (HTM) …

Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to
irreversible vision loss. Dysfunction of trabecular meshwork (TM) tissue, a major regulator of …

Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is
associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in …

The trabecular meshwork (TM) is the main site of drainage of the aqueous humor, and its
dysfunction leads to intraocular pressure elevation, which is one of the main risk factors of …