▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1
infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains …

The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood
although apoptosis has been proposed as a key mechanism. We now show that caspase-3 …

Unlike activated CD4+ T cells, resting CD4+ T cells are highly resistant to productive HIV-1
infection,,,,,,,. Early after HIV-1 entry, a major block limits reverse transcription of incoming …

HIV infection is associated with the progressive loss of CD4+ T cells through their
destruction or decreased production,. A central, yet unresolved issue of HIV disease is the …

The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly
understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced …

Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …

During cell division, mitotic spindles are assembled by microtubule-based motor proteins,.
The bipolar organization of spindles is essential for proper segregation of chromosomes …

As an early event in the viral life cycle, the entry of enveloped viruses into target cells has
received considerable attention. Viral fusion to cellular targets has been studied principally …

A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of
the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can …