The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases …

The pharmaceutical inactivation of driver oncogenes has revolutionized the treatment of
cancer, replacing cytotoxic chemotherapeutic approaches with kinase inhibitor therapies for …

NVP-BEZ235 is a dual phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin
(mTOR) inhibitor. A dual approach targeting more than one downstream effector is a …

Background: Human epidermal growth factor receptor 2 (HER2) is a well-developed
therapeutic target in breast and gastric cancer (GC). However, the impact of HER2 on …

Nrg1β is critically involved in cardiac development and also maintains function of the adult
heart. Studies conducted in animal models showed that it improves cardiac performance …

Src and the mammalian target of rapamycin (mTOR) signaling are commonly activated in
non-small cell lung cancer (NSCLC) and hence potential targets for chemotherapy. Although …

This study aims to investigate the immunomodulatory effect of anthocyanins (ANTs) from
Oryza sativa L. extracts on 5-fluorouracil (5-FU)-induced oral mucositis, using a rat model …

Abstract Purpose 5-Fluorouracil (5-FU) is the basic chemotherapeutic agent used to treat
colon cancer. However, the sensitivity of colon cancer cells to 5-FU is limited. Gossypol is a …

Fluorouracil (5-FU) is a chemotherapeutic agent used in the treatment of colorectal cancer.
In this study, we investigated whether 5-FU induces Sestrin2 (SESN2), an antioxidant …

Since the beginning of SESN protein development, they have attracted highly progressive
attention due to their regulatory role in multiple signalling pathways. Through their …