The liver is an important site for iron and lipid metabolism and the main site for the
interactions between these two metabolic pathways. Although conflicting results have been …

Studies carried out during the last few decades have consistently shown that cell surface
MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen …

This study was conducted to determine the interaction of individual corrosion products from
biodegradable iron stents with cells from the adjacent tissue. The response of human …

Background/Aims Natural killer T (NKT) cells have been recently reported to concern with
various lipid disorders. The role of NKT cells in the hepatic lipid disorder, nonalcoholic fatty …

Invariant NKT cells (iNKT cells) recognize glycolipid Ags via an invariant TCR α-chain and
play a central role in various immune responses. Although human CD4+ and CD4− iNKT …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron …

Invariant natural killer T-cells ('iNKT') are the best-known CD1d-restricted T-cells, with
recently-defined roles in controlling adaptive immunity. CD1d-restricted T-cells can rapidly …

Fabry disease is an X‐linked lysosomal storage disorder of glycosphingolipid catabolism
due to the deficient activity of the enzyme alpha‐galactosidase A. The non‐degraded …

Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing
NKR. Although the origin of this population remains controversial, it is possible to speculate …

Gaucher disease (GD) is an autosomal recessive inherited defect of the lysosomal enzyme
glucocerebrosidase (GluCerase) that leads to glucosylceramide (GluCer) accumulation. We …