The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our
modern society that combines chemistry and pharmacology with the aim of designing and …

HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …

Two novel bithienyl fluorobenzamidine derivatives namely, 4-([2, 2′: 5′, 2′′-
terthiophen]-5-yl)-2-fluorobenzamidine hydrochloride salt (MA-1615), 5′-(4-amidino-3 …

HOX proteins are transcription factors that regulate stem cell (SC) function, but their role in
the SC origin of cancer is under-studied. Aberrant expression of HOX genes occurs in many …

Newly designed and synthesized cyano, amidino and acrylonitrile 2, 5-disubstituted furane
derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for …

Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to
pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively …

Coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV and influenza A virus,
require the host proteases to mediate viral entry into cells. Rather than targeting the …

New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling
reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide …

The rational design of small molecules that target specific DNA sequences is a promising
strategy to modulate gene expression. This report focuses on a diamidinobenzimidazole …