Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Epigenetic aberrations in human pluripotent stem cells
S Bar, N Benvenisty - The EMBO journal, 2019 - embopress.org
Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in
investigating human development, and modeling and discovering therapies for a wide range …
investigating human development, and modeling and discovering therapies for a wide range …
The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome
Parental imprinting is a form of epigenetic regulation that results in parent-of-origin
differential gene expression. To study Prader-Willi syndrome (PWS), a developmental …
differential gene expression. To study Prader-Willi syndrome (PWS), a developmental …
Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors
The recent finding that reprogrammed human pluripotent stem cells can be derived by
nuclear transfer into human oocytes as well as by induced expression of defined factors has …
nuclear transfer into human oocytes as well as by induced expression of defined factors has …
Creating patient-specific neural cells for the in vitro study of brain disorders
As a group, we met to discuss the current challenges for creating meaningful patient-specific
in vitro models to study brain disorders. Although the convergence of findings between …
in vitro models to study brain disorders. Although the convergence of findings between …
How does reprogramming to pluripotency affect genomic imprinting?
V Perrera, G Martello - Frontiers in Cell and Developmental Biology, 2019 - frontiersin.org
Human induced Pluripotent Stem Cells (hiPSCs) have the capacity to generate a wide range
of somatic cells, thus representing an ideal tool for regenerative medicine. Patient-derived …
of somatic cells, thus representing an ideal tool for regenerative medicine. Patient-derived …
High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues
Purpose The aberrant mRNA expression of a UPR component Cation transport regulator
homolog 1 (CHAC1) has been reported to be associated with poor survival in breast and …
homolog 1 (CHAC1) has been reported to be associated with poor survival in breast and …
Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients
Background: The role of CHAC1 (cation transport regulator-like protein 1), a recently
identified component of the unfolded protein response (UPR) pathway, in gynaecological …
identified component of the unfolded protein response (UPR) pathway, in gynaecological …
Systematic review of induced pluripotent stem cell technology as a potential clinical therapy for spinal cord injury
AS Kramer, AR Harvey, GW Plant… - Cell …, 2013 - journals.sagepub.com
Transplantation therapies aimed at repairing neurodegenerative and neuropathological
conditions of the central nervous system (CNS) have utilized and tested a variety of cell …
conditions of the central nervous system (CNS) have utilized and tested a variety of cell …
Expanding the boundaries of embryonic stem cells
U Ben-David, O Kopper, N Benvenisty - Cell Stem Cell, 2012 - cell.com
The boundaries of embryonic stem cell (ESC) research have extended considerably in
recent years in several important ways. Alongside a deeper understanding of the pluripotent …
recent years in several important ways. Alongside a deeper understanding of the pluripotent …