Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer's and
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …

Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

O-GlcNAc is a common modification found on nuclear and cytoplasmic proteins.
Determining the catalytic mechanism of the enzyme O-GlcNAcase (OGA), which removes O …

Abstract O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic and reversible
posttranslational modification that targets serine and threonine residues in a variety of …

Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

Glycosylation is a common post-translational modification of brain proteins including cell
surface adhesion molecules, synaptic proteins, receptors and channels, as well as …

Inhibiting O-GlcNAcase and thereby up-regulation of the O-GlcNAc levels of tau was a
potential approach for discovering AD treatments. Herein, a series of novel highly potent …