Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …

Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …

Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …

Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2. 1.1) has
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …

A series of ureas derived from phenethylamines were synthesized and evaluated for human
carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase …

Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

Introduction: The hydration/dehydration of CO2 catalyzed by carbonic anhydrases (CAs, EC
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …