Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm: possible therapeutic targets?

S Kumar, RA Boon, L Maegdefessel… - Circulation …, 2019 - Am Heart Assoc
Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall
and is among the most challenging cardiovascular diseases as without urgent surgical …

Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

[HTML][HTML] Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease

E Biros, G Gäbel, CS Moran, C Schreurs… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) represent common
causes of morbidity and mortality in elderly populations which were previously believed to …

Surrogate markers of abdominal aortic aneurysm progression

A Wanhainen, K Mani, J Golledge - … , thrombosis, and vascular …, 2016 - Am Heart Assoc
The natural course of many abdominal aortic aneurysms (AAA) is to gradually expand and
eventually rupture and monitoring the disease progression is essential to their management …

Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2

CS Moran, E Biros, SM Krishna, Y Wang… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Recent evidence suggests an important role for angiotensin-converting enzyme
2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of …

Non-coding RNA contribution to thoracic and abdominal aortic aneurysm disease development and progression

Y Li, L Maegdefessel - Frontiers in physiology, 2017 - frontiersin.org
Multiple research groups have started to uncover the complex genetic and epigenetic
machinery necessary to maintain cardiovascular homeostasis. In particular, the key …

Inhibition of microRNA-155 attenuates sympathetic neural remodeling following myocardial infarction via reducing M1 macrophage polarization and inflammatory …

J Hu, CX Huang, PP Rao, JP Zhou, X Wang… - European journal of …, 2019 - Elsevier
Inflammation plays an important role in sympathetic neural remodeling induced by
myocardial infarction (MI). MiR-155 is a vital regulator of inflammatory responses, and …

miR-195 suppresses abdominal aortic aneurysm through the TNF-α/NF-κB and VEGF/PI3K/Akt pathway

X Ma, H Yao, Y Yang, L Jin… - International …, 2018 - spandidos-publications.com
In the present study, the function of microRNA (miR)‑195 on abdominal aortic aneurysm
(AAA) and its possible mechanism were investigated. Reverse transcription‑quantitative …

Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease

PW Stather, N Sylvius, DA Sidloff… - Journal of British …, 2015 - academic.oup.com
Background MicroRNAs are crucial in the regulation of cardiovascular disease and
represent potential therapeutic targets to decrease abdominal aortic aneurysm (AAA) …

The emerging role of microRNA‐155 in cardiovascular diseases

RY Cao, Q Li, Y Miao, Y Zhang, W Yuan… - BioMed research …, 2016 - Wiley Online Library
MicroRNAs have been demonstrated to be involved in human diseases, including
cardiovascular diseases. Growing evidences suggest that microRNA‐155, a typical …