Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

Among heterocyclic compounds, quinoline scaffold has become an important construction
motif for the development of new drugs. Quinoline and its derivatives possess many types of …

Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …

Heterocycles form, by far, the largest of the classical divisions of organic chemistry.
Moreover, they are of immense importance not only biologically and industrially but also to …

The medicine man of prehistoric time knew of the healing capacity of leaves, oils, extracts,
roots, etc. from the surrounding flora. A widely acknowledged example of natural medicine …

A series of substituted 2-phenylbenzimidazole-4-carboxamides has been synthesized and
evaluated for in vitro and in vivo antitumor activity. These compounds represent the logical …

Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …

A series of phenyl-substituted derivatives of the “minimal” DNA-intercalating agent IV-[2-
(dimethylamino)-ethyl]-2-phenylquinoline-8-carboxamide (1) have been synthesized and …

Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …

A series of acridine-substituted bis (acridine-4-carboxamides) linked by a (CH2) 3N
(Me)(CH2) 3 chain have been prepared by reaction of the isolated imidazolides of the …