Social determinants of cardiovascular disease

TM Powell-Wiley, Y Baumer, FO Baah… - Circulation …, 2022 - Am Heart Assoc
Social determinants of health (SDoH), which encompass the economic, social,
environmental, and psychosocial factors that influence health, play a significant role in the …

DunedinPACE, a DNA methylation biomarker of the pace of aging

DW Belsky, A Caspi, DL Corcoran, K Sugden… - Elife, 2022 - elifesciences.org
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Understanding the health effects of caregiving stress: New directions in molecular aging

LM Christian, SJ Wilson, AA Madison… - Ageing Research …, 2023 - Elsevier
Dementia caregiving has been linked to multiple health risks, including infectious illness,
depression, anxiety, immune dysregulation, weakened vaccine responses, slow wound …

In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures

LL Schmitz, V Duque - … of the National Academy of Sciences, 2022 - National Acad Sciences
Research on maternal-fetal epigenetic programming argues that adverse exposures to the
intrauterine environment can have long-term effects on adult morbidity and mortality …

Association of pace of aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia

K Sugden, A Caspi, ML Elliott, KJ Bourassa… - Neurology, 2022 - AAN Enterprises
Background and Objectives DNA methylation algorithms are increasingly used to estimate
biological aging; however, how these proposed measures of whole-organism biological …

[HTML][HTML] DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project …

AK Bozack, SL Rifas-Shiman, DR Gold, ZM Laubach… - Clinical …, 2023 - Springer
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration
(EGAA) are biomarkers of physiological development and may be affected by the perinatal …

Evaluating the continued integration of genetics into medical sociology

JD Boardman, JM Fletcher - Journal of Health and Social …, 2021 - journals.sagepub.com
The 2010 special issue of Journal of Health and Social Behavior, titled “Fifty Years of
Medical Sociology,” defined the contours of the medical sociological perspective. We use …

Structural racism in primary schools and changes in epigenetic age acceleration among Black and White youth

CD Martz, AD Benner, BJ Goosby, C Mitchell… - Social Science & …, 2024 - Elsevier
Structural racism generates racial inequities in US primary education, including segregated
schools, inequitable funding and resources, racial disparities in discipline and achievement …

Short sleep and insomnia are associated with accelerated epigenetic age

CDJ Kusters, ET Klopack, EM Crimmins… - Psychosomatic …, 2024 - journals.lww.com
Objective Short sleep and insomnia are each associated with a greater risk of age-related
disease, which suggests that insufficient sleep may accelerate biological aging. We examine …

Association of race and poverty status with DNA methylation–based age

B Shen, NA Mode, NN Hooten, NL Pacheco… - JAMA Network …, 2023 - jamanetwork.com
Importance The Dunedin Pace of Aging Calculated From the Epigenome (DunedinPACE)
measure is a newly constructed DNA methylation (DNAm) biomarker associated with …