Highlights•With no available cure, treatment of HIV infection requires life-long therapy.•A
combination of three drugs is the current standard for chronic HIV therapy.•Multiple single …

Despite substantial progress in the development of antiretroviral regimens that durably
suppress Human Immunodeficiency Virus (HIV) infection, new agents that maintain high …

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …

This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

BACKGROUND: Combination antiretroviral therapy has led to significant increases in
survival and quality of life, but at a population-level the effect on life expectancy is not well …

Background Despite declines in morbidity and mortality with the use of combination
antiretroviral therapy, its effectiveness is limited by adverse events, problems with …

Background The population infected with HIV is getting older and these people will
increasingly develop age-related non-communicable diseases (NCDs). We aimed to …

Background: AIDS-related death and disease rates have declined in the highly active
antiretroviral therapy (HAART) era and remain low; however, current causes of death in …

Background Mortality among HIV‐infected persons is decreasing, and causes of death are
changing. Classification of deaths is hampered because of low autopsy rates, frequent …

Background Insufficient data are available from single cohort studies to allow estimation of
the prognosis of HIV-1 infected, treatment-naive patients who start highly active antiretroviral …