Lymphopenia caused by virus infections and the mechanisms beyond

Z Guo, Z Zhang, M Prajapati, Y Li - Viruses, 2021 - mdpi.com
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …

When the damage is done: injury and repair in thymus function

S Kinsella, JA Dudakov - Frontiers in immunology, 2020 - frontiersin.org
Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …

Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling

P Bohacova, M Terekhova, P Tsurinov, R Mullins… - Immunity, 2024 - cell.com
Thymic involution is a key factor in human immune aging, leading to reduced thymic output
and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the …

Thymic microenvironment: Interactions between innate immune cells and developing thymocytes

H Wang, JC Zúñiga-Pflücker - Frontiers in Immunology, 2022 - frontiersin.org
The thymus is a crucial organ for the development of T cells. T cell progenitors first migrate
from the bone marrow into the thymus. During the journey to become a mature T cell …

Tolerance has its limits: how the thymus copes with infection

C Nunes-Alves, C Nobrega, SM Behar… - Trends in …, 2013 - cell.com
The thymus is required for T cell differentiation; a process that depends on which antigens
are encountered by thymocytes, the environment surrounding the differentiating cells, and …

Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses

A Fox, LNM Hoa, P Horby, HR van Doorn, NV Trung… - PloS one, 2012 - journals.plos.org
Background It is unclear why the severity of influenza varies in healthy adults or why the
burden of severe influenza shifts to young adults when pandemic strains emerge. One …

Screening of antiviral components of Ma Huang Tang and investigation on the ephedra alkaloids efficacy on influenza virus type A

W Wei, H Du, C Shao, H Zhou, Y Lu, L Yu… - Frontiers in …, 2019 - frontiersin.org
Although Ma Huang Tang (MHT) has long been considered as a classical formula for
respiratory infections like influenza, bronchitis and asthma, its chemical ingredients that …

Modeling the dynamics of T-cell development in the thymus

PA Robert, H Kunze-Schumacher, V Greiff, A Krueger - Entropy, 2021 - mdpi.com
The thymus hosts the development of a specific type of adaptive immune cells called T cells.
T cells orchestrate the adaptive immune response through recognition of antigen by the …

The human thymus perivascular space is a functional niche for viral-specific plasma cells

S Nuñez, C Moore, B Gao, K Rogers, Y Hidalgo… - Science …, 2016 - science.org
The human thymus is susceptible to viral infections that can severely alter thymopoiesis and
compromise the mechanisms of acquired tolerance to self-antigens. In humans, plasma cells …

Severe influenza A (H1N1) pdm09 infection induces thymic atrophy through activating innate CD8+ CD44hi T cells by upregulating IFN-γ

B Liu, X Zhang, W Deng, J Liu, H Li, M Wen… - Cell Death & …, 2014 - nature.com
Thymic atrophy has been described as a consequence of infection by several pathogens
including highly pathogenic avian influenza virus and is induced through diverse …