The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …

Currently, metabolic surgery (MS) constitutes the most effective means for durable weight
loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non …

Abstract Uncoupling protein 1 (UCP1) has been discovered as a possible target for obesity
treatment because of its widespread distribution in the inner mitochondrial membrane of …

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

Context Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to exert
insulin-independent effects on lipid and bone metabolism. Objective We investigated the …

Alzheimer's disease (AD) is a leading cause of cognitive impairment worldwide. Overweight
and obesity are strongly associated with comorbidities, such as hypertension, diabetes, and …

Activation of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) upon cold
stimulation leads to substantial increase in energy expenditure to defend body temperature …