The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

As a member of the TRIM (tripartite motif) protein family, TRIM56 can function as an E3
ubiquitin ligase. In addition, TRIM56 has been shown to possess deubiquitinase activity and …

Acute injury to the central nervous system (CNS) remains a complex and challenging clinical
need. CNS injury initiates a dynamic neuroinflammatory response, mediated by both …

There are few effective and safe neuroprotective agents for the treatment of ischemic stroke
currently. Caffeic acid is a phenolic acid that widely exists in a number of plant species …

The interaction between the peripheral immune system and the brain is increasingly being
recognized as an important layer of neuroimmune regulation and plays vital roles in brain …

Microglia and monocytes play a critical role in immune responses to cerebral ischemia.
Previous studies have demonstrated that interferon regulatory factor 4 (IRF4) and IRF5 direct …

The aging of the global population poses significant scientific challenges. Moreover, the
biological process of aging is the most significant risk factor for most chronic illnesses; …

Ischemic stroke, a common neurological disorder caused by impaired blood supply to the
brain, presents a therapeutic challenge. Conventional treatments like thrombolysis and …

RNA splicing is a post-transcriptional event that regulates many physiological and
pathological events. However, whether RNA splicing regulates cerebral I/R-induced brain …

The regeneration capacity after an injury is critical to the survival of living organisms. In
animals, regeneration ability can be classified into five primary types: cellular, tissue, organ …