Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Human gene expression is regulated by more than 2,000 transcription factors and chromatin
regulators,. Effector domains within these proteins can activate or repress transcription …

Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs
have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for …

We recently showed that the mammalian genome encodes> 1,000 large intergenic
noncoding (linc) RNAs that are clearly conserved across mammals and, thus, functional …

Neurogenic transcription factors and evolutionarily conserved signalling pathways have
been found to be instrumental in the formation of neurons,. However, the instructive role of …

Highlights•Identified as a master regulator of neuronal genes in embryogenesis, REST is a
common theme in neurodegeneration.•Whereas bioinformatics predicts∼ 2000 REST …

The post-translational modification SUMOylation is a major regulator of protein function that
plays an important role in a wide range of cellular processes. SUMOylation involves the …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Tumor–stromal communications impact tumorigenesis in ways that are incompletely
understood. Here, we show that glioma-associated human mesenchymal stem cells (GA …