Updates in diagnosing polycystic ovary syndrome-related infertility

H Haddad-Filho, JAG Tosatti, FM Vale… - Expert Review of …, 2023 - Taylor & Francis
Introduction Polycystic ovary syndrome (PCOS) is a condition that affects approximately 13%
of reproductive age women and is characterized by androgen excess, menstrual irregularity …

[HTML][HTML] Recent advances in understanding gonadotropin signaling

L Casarini, M Simoni - Faculty reviews, 2021 - ncbi.nlm.nih.gov
Gonadotropins are glycoprotein sex hormones regulating development and reproduction
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …

Structure-function relationships of the follicle-stimulating hormone receptor

A Ulloa-Aguirre, T Zariñán, E Jardón-Valadez… - Frontiers in …, 2018 - frontiersin.org
The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This
structurally complex receptor is a member of the G-protein coupled receptor (GPCR) …

Effect of genetic variants of gonadotropins and their receptors on ovarian stimulation outcomes: a delphi consensus

A Conforti, F Tüttelmann, C Alviggi, HM Behre… - Frontiers in …, 2022 - frontiersin.org
Background A Delphi consensus was conducted to evaluate the influence of single
nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin …

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

B Bianco, FA Loureiro, CM Trevisan… - Frontiers in …, 2021 - frontiersin.org
Background Single nucleotide variants (SNVs) FSHB: c.-211G> T, FSHR: c. 919G> A, and
FSHR: c. 2039G> A were reported to be associated with the variability in FSH and LH levels …

Pharmacogenetics of FSH Action in the Female

A Conforti, A Vaiarelli, D Cimadomo… - Frontiers in …, 2019 - frontiersin.org
The purpose of a pharmacogenomic approach is to tailor treatment on the basis of an
individual human genotype. This strategy is becoming increasingly common in medicine …

The effect of the allelics of Ser680Asn polymorphisms of follicle-stimulating hormone receptor gene in IVF/ICSI cycles: a systematic review and meta-analysis

A Prodromidou, E Dimitroulia, D Mavrogianni… - Reproductive …, 2023 - Springer
A significant number of single-nucleotide polymorphisms (SNPs) of the follicle-stimulating
hormone receptor (FSHr) can modify the response to exogenous FSH administration. A …

Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high …

B Monge-Ochoa, L Montoro, E Gil-Arribas… - Journal of Assisted …, 2021 - Springer
Purpose To determine the influence of different genotypes of Ala307Thr and Asn680Ser
FSHr polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy …

A novel mutation in the FSH receptor (I423T) affecting receptor activation and leading to primary ovarian failure

T Zariñán, J Mayorga, E Jardón-Valadez… - The Journal of …, 2021 - academic.oup.com
Context Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-
of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent …

Associations of FSHR and LHCGR gene variants with ovarian reserve and clinical pregnancy rates

C Guo, H Yu, G Feng, Q Lv, X Liu, X Liu - Reproductive BioMedicine Online, 2021 - Elsevier
Research question Are there any associations between the variants of FSHR c. 2039 G> A
(p. Ser680Asn, rs6166) and LHCGR c. 935A> G (p. Asn312Ser, rs2293275) and ovarian …