Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis
E Gracey, L Vereecke, D McGovern… - Nature Reviews …, 2020 - nature.com
Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …
HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome
M Asquith, PR Sternes, ME Costello… - Arthritis & …, 2019 - Wiley Online Library
Objective HLA alleles affect susceptibility to more than 100 diseases, but the mechanisms
that account for these genotype–disease associations are largely unknown. HLA alleles …
that account for these genotype–disease associations are largely unknown. HLA alleles …
[HTML][HTML] Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database
M Arévalo, J Gratacós Masmitjà, M Moreno… - Arthritis research & …, 2018 - Springer
Abstract Objective To assess HLA-B27 influence on the clinical phenotype of Ankylosing
Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of …
Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of …
Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis
JD Reveille - Clinical rheumatology, 2015 - Springer
With the growing awareness of the impact of chronic back pain and axial spondyloarthritis
and recent breakthroughs in genetics and the development of novel treatments which may …
and recent breakthroughs in genetics and the development of novel treatments which may …
Biomarker development for axial spondyloarthritis
The term axial spondyloarthritis (axSpA) encompasses a heterogeneous group of diseases
that have variable presentations, extra-articular manifestations and clinical outcomes, and …
that have variable presentations, extra-articular manifestations and clinical outcomes, and …
[HTML][HTML] Genetics and functional genomics of spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disorder with high heritability but with
complex genetics. It encompasses several entities that share common clinical features. Most …
complex genetics. It encompasses several entities that share common clinical features. Most …
[HTML][HTML] DKK-1 is underexpressed in mesenchymal stem cells from patients with ankylosing spondylitis and further downregulated by IL-17
D Daoussis, A Kanellou, E Panagiotopoulos… - International Journal of …, 2022 - mdpi.com
Dickkopf-1 (Dkk-1) is a key regulator of bone remodeling in spondyloarthropathies.
Nevertheless, data regarding its expression in cells of pathophysiologic relevance, such as …
Nevertheless, data regarding its expression in cells of pathophysiologic relevance, such as …
Genetics and the axial spondyloarthritis spectrum
The axial SpAs (axSpAs) are clearly clinically a heterogeneous set of diseases with
markedly varying extra-articular features. These diseases are all highly heritable and have …
markedly varying extra-articular features. These diseases are all highly heritable and have …
Ankylosing spondylitis: HLA-B* 27-positive versus HLA-B* 27-negative disease
Abstract Purpose of Review We review our current knowledge about the clinical features of
patients with ankylosing spondylitis (AS) who possess HLA-B* 27 versus those who lack this …
patients with ankylosing spondylitis (AS) who possess HLA-B* 27 versus those who lack this …