Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …

Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …

Autophagy and endoplasmic reticulum (ER) stress are conserved processes that generally
promote survival, but can induce cell death when physiological thresholds are crossed. The …

Purpose: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK,
also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation …

Purpose: The integrated stress response (ISR) kinase PERK serves as a survival factor for
both proliferative and dormant cancer cells. We aim to validate PERK inhibition as a new …

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite
therapeutic advances, long term survival in patients diagnosed with advanced disease is …

Renal cell carcinoma (RCC) is the most common renal malignancy with a rapidly increasing
morbidity and mortality rate gradually. RCC has a high mortality rate and an extremely poor …

Background Clear cell renal cell carcinoma (ccRCC) plays a significant role in the mortality
associated with kidney cancer. Targeting biological processes that inhibit cancer growth …

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three
endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response …

A series of activators of GCN2 (general control nonderepressible 2) kinase have been
developed, leading to HC-7366, which has entered the clinic as an antitumor therapy …