Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
J Gao, HA Pickett - Nature Reviews Cancer, 2022 - nature.com
Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
Telomere length maintenance in cancer: at the crossroad between telomerase and alternative lengthening of telomeres (ALT)
M De Vitis, F Berardinelli, A Sgura - International journal of molecular …, 2018 - mdpi.com
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …
Role of telomere length in human carcinogenesis
A Tsatsakis, T Oikonomopoulou… - International …, 2023 - spandidos-publications.com
Cancer is considered the most important clinical, social and economic issue regarding
cause‑specific disability‑adjusted life years among all human pathologies. Exogenous …
cause‑specific disability‑adjusted life years among all human pathologies. Exogenous …
Telomere maintenance mechanisms in cancer
T Bordeira Gaspar, A Sá, JM Lopes… - Genes, 2018 - mdpi.com
Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …
shortening, an inevitable process due to successive cell divisions. In most tumour cells …
Telomere function and regulation from mouse models to human ageing and disease
C Jones-Weinert, L Mainz, J Karlseder - Nature Reviews Molecular Cell …, 2024 - nature.com
Telomeres protect the ends of chromosomes but shorten following cell division in the
absence of telomerase activity. When telomeres become critically short or damaged, a DNA …
absence of telomerase activity. When telomeres become critically short or damaged, a DNA …
Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma
Deep learning has emerged as the technique of choice for identifying hidden patterns in cell
imaging data but is often criticized as" black box." Here, we employ a generative neural …
imaging data but is often criticized as" black box." Here, we employ a generative neural …
Telomere maintenance mechanisms define clinical outcome in high-risk neuroblastoma
Neuroblastoma is a childhood cancer with heterogeneous clinical outcomes. To
comprehensively assess the impact of telomere maintenance mechanism (TMM) on clinical …
comprehensively assess the impact of telomere maintenance mechanism (TMM) on clinical …
ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156
Cancers overcome replicative immortality by activating either telomerase or an alternative
lengthening of telomeres (ALT) mechanism. ALT occurs in~ 25% of high-risk …
lengthening of telomeres (ALT) mechanism. ALT occurs in~ 25% of high-risk …
Telomerase activation and ATRX mutations are independent risk factors for metastatic pheochromocytoma and paraganglioma
Abstract Purpose: Pheochromocytomas and paragangliomas (PPGLs) are rare
neuroendocrine tumors. Whereas most PPGLs are benign, up to 20% may become …
neuroendocrine tumors. Whereas most PPGLs are benign, up to 20% may become …
[HTML][HTML] Extensive proliferation of human cancer cells with ever-shorter telomeres
RA Dagg, HA Pickett, AA Neumann, CE Napier… - Cell reports, 2017 - cell.com
Acquisition of replicative immortality is currently regarded as essential for malignant
transformation. This is achieved by activating a telomere lengthening mechanism (TLM) …
transformation. This is achieved by activating a telomere lengthening mechanism (TLM) …