Abstract Fragile X Syndrome (FXS) is the most common form of inherited intellectual
disability due to the silencing of the FMR1 gene encoding FMRP (Fragile X Mental …

The fragile X mental retardation 1 gene, which codes for the fragile X mental retardation 1
protein, usually has 5 to 40 CGG repeats in the 5'untranslated promoter. The full mutation is …

Recent data from a national survey highlighted a significant difference in obesity rates in
young fragile X males (31%) compared to age matched controls (18%). Fragile X syndrome …

Work in recent years has revealed an abundance of possible new treatment targets for
fragile X syndrome (FXS). The use of animal models, including the fragile X knockout mouse …

Valproic acid administration during gestational period causes behavior and biochemical
deficits similar to those observed in humans with autism spectrum disorder. Although …

Fragile X Syndrome (FXS) is the most common single-gene inherited form of intellectual
disability with behaviors characteristic of autism. People with FXS display childhood …

Sleep has numerous advantages for aligning clinical and preclinical (basic neuroscience)
studies of neuropsychiatric illness. Sleep has high translational relevance, because the …

Fragile X syndrome (FXS), a severe neurodevelopmental anomaly, and one of the earliest
disorders linked to an unstable ('dynamic') mutation, is caused by the large (> 200) CGG …

Sleep is important for neural plasticity, and plasticity underlies sleep-dependent memory
consolidation. It is widely appreciated that protein synthesis plays an essential role in neural …

Fragile X syndrome (FXS) is the most common single gene cause of intellectual disability
and it is characterized by a CGG expansion of more than 200 repeats in the FMR1 gene …