SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

H Dubey, RK Sharma, S Krishnan… - Frontiers in …, 2022 - frontiersin.org
Pregnant women constitute one of the most vulnerable populations to be affected by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of coronavirus …

Let's get physical: flavivirus-host protein–protein interactions in replication and pathogenesis

AT Fishburn, OH Pham, MW Kenaston… - Frontiers in …, 2022 - frontiersin.org
Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …

RIG-I and MDA5 are modulated by bone morphogenetic protein (BMP6) and are essential for restricting Zika virus infection in human Sertoli cells

B Jiyarom, S Giannakopoulos, DP Strange… - Frontiers in …, 2023 - frontiersin.org
Sexual transmission of Zika virus (ZIKV) is associated with virus persistence in the testes
and shedding in the seminal fluid for months after recovery. We previously demonstrated …

The Epidermal Growth Factor Receptor Is a Relevant Host Factor in the Early Stages of The Zika Virus Life Cycle In Vitro

C Sabino, D Bender, ML Herrlein, E Hildt - Journal of virology, 2021 - Am Soc Microbiol
Zika virus (ZIKV) is a flavivirus that is well known for the epidemic in the Americas in 2015
and 2016 in which microcephaly in newborns and other neurological complications were …

The interplay between brain vascular calcification and microglia

U Maheshwari, SF Huang, S Sridhar… - Frontiers in Aging …, 2022 - frontiersin.org
Vascular calcifications are characterized by the ectopic deposition of calcium and phosphate
in the vascular lumen or wall. They are a common finding in computed tomography scans or …

[HTML][HTML] Insights into the structure, functional perspective, and pathogenesis of ZIKV: an updated review

EA Bhat, T Ali, N Sajjad, P Bron - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Zika virus (ZIKV) poses a serious threat to the entire world. The rapid spread of ZIKV and
recent outbreaks since 2007 have caused worldwide concern about the virus. Diagnosis is …

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

CCS Caetano, T Azamor, NM Meyer… - Nature …, 2024 - nature.com
Bone-related diseases (osteopathologies) associated with human virus infections have
increased around the globe. Recent findings have highlighted the intricate interplay …

Zika Virus and Neuropathogenesis: The Unanswered Question of Which Strain Is More Prone to Causing Microcephaly and Other Neurological Defects

EL King, N Irigoyen - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Despite being perceived to be a relatively innocuous pathogen during its circulation in Africa
in the 20th century, consequent outbreaks in French Polynesia and Latin America revealed …

Microcephaly protein ANKLE2 promotes Zika virus replication

AT Fishburn, CJ Florio, TN Klaessens, B Prince… - mBio, 2025 - journals.asm.org
Orthoflaviviruses are positive-sense single-stranded RNA viruses that hijack host proteins to
promote their own replication. Zika virus (ZIKV) is infamous among orthoflaviviruses for its …

Sustained chronic inflammation and altered childhood vaccine responses in children exposed to Zika virus

SS Foo, W Chen, T Azamor, KL Jung, MC Cambou… - Ebiomedicine, 2024 - thelancet.com
Summary Background Congenital Zika virus (ZIKV) infection leads to severe newborn
abnormalities, but its long-term impact on childhood immunity is not well understood. This …