Updates on the pathogenicity status of Pseudomonas aeruginosa

MW Azam, AU Khan - Drug discovery today, 2019 - Elsevier
Highlights•MDR P. aeruginosa is one of the major causes of the nosocomial
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …

Plant-derived inhibitors of AHL-mediated quorum sensing in bacteria: Modes of action

D Deryabin, A Galadzhieva, D Kosyan… - International Journal of …, 2019 - mdpi.com
Numerous gram-negative phytopathogenic and zoopathogenic bacteria utilise acylated
homoserine lactone (AHL) in communication systems, referred to as quorum sensing (QS) …

[HTML][HTML] Screening strategies for quorum sensing inhibitors in combating bacterial infections

L Lu, M Li, G Yi, L Liao, Q Cheng, J Zhu… - Journal of …, 2022 - Elsevier
Interference with quorum sensing (QS) represents an antivirulence strategy with significant
promise for the treatment of bacterial infections and a new approach for restoring antibiotic …

PqsE expands and differentially modulates the RhlR quorum sensing regulon in Pseudomonas aeruginosa

M Letizia, M Mellini, A Fortuna, P Visca… - Microbiology …, 2022 - Am Soc Microbiol
In the opportunistic pathogen Pseudomonas aeruginosa, many virulence traits are finely
regulated by quorum sensing (QS), an intercellular communication system that allows the …

Cheating on cheaters stabilizes cooperation in Pseudomonas aeruginosa

Ö Özkaya, R Balbontín, I Gordo, KB Xavier - Current Biology, 2018 - cell.com
Bacterial cooperation can be disrupted by non-producers that can profit from public goods
without paying their production cost. A cheater can increase in frequency, exhausting the …

High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa

A Vetrivel, S Natchimuthu, V Subramanian… - ACS …, 2021 - ACS Publications
Pseudomonas aeruginosa, an opportunistic human pathogen, causes fatal effects in
patients with cystic fibrosis and immunocompromised individuals and leads to around 1000 …

Antiactivators prevent self-sensing in Pseudomonas aeruginosa quorum sensing

P Smith, M Schuster - … of the National Academy of Sciences, 2022 - National Acad Sciences
Quorum sensing is described as a widespread cell density-dependent signaling mechanism
in bacteria. Groups of cells coordinate gene expression by secreting and responding to …

The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked …

F Ding, KI Oinuma, NE Smalley, AL Schaefer… - MBio, 2018 - Am Soc Microbiol
Pseudomonas aeruginosa uses two acyl-homoserine lactone signals and two quorum
sensing (QS) transcription factors, LasR and RhlR, to activate dozens of genes. LasR …

RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing

M Mellini, M Letizia, L Caruso, A Guiducci… - Mbio, 2023 - Am Soc Microbiol
In its canonical interpretation, quorum sensing (QS) allows single cells in a bacterial
population to synchronize gene expression and hence perform specific tasks collectively …

Pseudomonas aeruginosa isolates defective in function of the LasR quorum sensing regulator are frequent in diverse environmental niches

MC Groleau, H Taillefer, AT Vincent… - Environmental …, 2022 - Wiley Online Library
The saprophyte Pseudomonas aeruginosa is a versatile opportunistic pathogen causing
infections in immunocompromised individuals. To facilitate its adaptation to a large variety of …