The decline in the rate of new antibiotic discovery is of growing concern, and new
antibacterial strategies must now be explored. This review brings together research in two …

Cells regularly experience fluid flow in natural systems. However, most experimental
systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on …

The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental
conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the …

Microbial cytochrome c peroxidases (Ccp) have been studied for 75 years, but their
physiological roles are unclear. Ccps are located in the periplasms of bacteria and the …

Natural products that possess antibiotic and antitumor qualities are often suspected of
working through oxidative mechanisms. In this study, two quinone-based small molecules …

Antimicrobial-resistant bacteria pose a serious threat in the clinic. This is particularly true for
opportunistic pathogens that possess high intrinsic resistance. Though many studies have …

A wide variety of stresses have been proposed to exert killing effects upon bacteria by
stimulating the intracellular formation of reactive oxygen species (ROS). A key part of the …

Escherichia coli is a model organism that has been exploited to reveal key details of
hydrogen peroxide stress: the biomolecules that H 2 O 2 most rapidly damages and the …

Uropathogenic Escherichia coli (UPEC) UTI89 is a well-characterized strain, which has
mainly been used to study UPEC virulence during urinary tract infection (UTI). However, little …

Reactive oxygen species (ROS) cause damage to DNA and proteins. Here, we report that
the RecA recombinase is itself oxidized by ROS. Genetic and biochemical analyses …