A dietary therapy for pediatric epilepsy known as the ketogenic diet has seen a revival in its
clinical use during the past decade. Although the underlying mechanism of the diet remains …

Ketogenic diets: new advances for metabolism-based therapies : Current Opinion in Neurology
Ketogenic diets: new advances for metabolism-based therapies : Current Opinion in Neurology …

Epilepsy is a highly prevalent seizure disorder which tends to progress in severity and
become refractory to treatment. Yet no therapy is proven to halt disease progression or to …

The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can
also have antiepileptogenic properties and can eventually have a role in treating other …

The core symptoms of autism spectrum disorder are poorly treated with current medications.
Symptoms of autism spectrum disorder are frequently comorbid with a diagnosis of epilepsy …

High fat, low carbohydrate ketogenic diets (KD) have been in use for the treatment of
epilepsy for almost a hundred years. Remarkably, seizures that are resistant to conventional …

Prevention of epilepsy and its progression remains the most urgent need for epilepsy
research and therapy development. Novel conceptual advances are required to …

Metabolic dysfunction can underlie seizure disorders, and metabolism-based treatments can
afford seizure control and promote homeostasis. This relationship between metabolism and …

Chromatin modifications play a crucial role in the regulation of gene expression. The
repressor element-1 (RE1) silencing transcription factor (REST), also known as neuron …

REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is
known to repress thousands of possible target genes, many of which are neuron specific. To …