The adipocyte-derived 'satiety promoting'hormone, leptin, has been identified as a key
central regulator of body weight and fertility, such that its absence leads to obesity and …

A minimum amount of energy is required for basic physiological processes, such as protein
biosynthesis, thermoregulation, locomotion, cardiovascular function, and digestion …

Insulin action in the hypothalamus results in the suppression of hepatic glucose production
(HGP). Obesity is often associated with a diminished response to insulin, leading to impaired …

Recent work shows that gut microbial dysbiosis contributes to the risk of obesity in children
whose mothers consume a high-fat diet (HFD) during both gestation and lactation or during …

An individual's nutritional status has a powerful effect on sexual maturation. Puberty onset is
delayed in response to chronic energy insufficiency and is advanced under energy …

The hypothalamic ventral premammillary nucleus (PMv) is a glutamatergic nucleus essential
for the metabolic control of reproduction. However, conditional deletion of leptin receptor …

Hypothalamic inflammation and metabolic changes resulting from the consumption of high-
fat diets have been linked to low grade inflammation and obesity. Inflammation impairs the …

Anthropogenic climate change has led to globally increasing temperatures at an
unprecedented pace and, to persist, wild species have to adapt to their changing world. We …

Diets leading to caloric overload are linked to metabolic disorders and reproductive function
impairment. Metabolic and hormonal abnormalities stand out as defining features of …

Nutrition and growth are important signals for pubertal development, although how they are
perceived and integrated in brain circuits has not been well defined. Growth hormones and …