Cancer progression to the invasive and metastatic stage represents the most formidable
barrier to successful treatment. To develop rational therapies, we must determine the …

Colorectal cancer progression and survival is dependent on complex interactions between
the tumour and the host. The pronounced local inflammatory response in and around the …

Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …

Deriving interpretable prognostic features from deep-learning-based prognostic
histopathology models remains a challenge. In this study, we developed a deep learning …

AIM OF THE STUDY: Previous work has indicated that quantification of inflammatory cell
reaction is of prognostic value in colorectal cancer. We evaluated the prognostic significance …

Background In colorectal cancer, the morphology of the invasive tumor margin may reflect
aggressiveness of tumor growth, thus providing important prognostic information. The tumor …

Background Infiltrative growth pattern at the tumor margin has been associated with shorter
patient survival. However, little is known about the prognostic significance of tumor growth …

Histomorphological features of colorectal cancers (CRC) represent valuable prognostic
indicators for clinical decision making. The invasive margin is a central feature for …

Background: The host inflammatory response is an important determinant of cancer
outcome. We examined different methods of assessing the local inflammatory response in …

The nature of the invasive growth pattern and microvessel density (MVD) have been
suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal …