Genetics of donor cell leukemia in acute myelogenous leukemia and myelodysplastic syndrome

L Williams, K Doucette, JE Karp, C Lai - Bone marrow transplantation, 2021 - nature.com
Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapeutic
modality for patients with acute myelogenous leukemia (AML) with poor risk features …

Clonal hematopoiesis of indeterminate potential as a novel risk factor for donor-derived leukemia

SS Burns, R Kapur - Stem Cell Reports, 2020 - cell.com
Hematopoietic stem cell transplantation (HSCT) is a critical treatment modality for many
hematological and non-hematological diseases that is being extended to treat older …

Short tandem repeats (STRs) as biomarkers for the quantitative follow-up of chimerism after stem cell transplantation: methodological considerations and clinical …

A Navarro-Bailón, D Carbonell, A Escudero, M Chicano… - Genes, 2020 - mdpi.com
Chimerism refers to the relative proportion of donor and recipient DNA after hematopoietic
stem cell transplantation (HSCT) and its quantitative follow-up is of great clinical utility in this …

[HTML][HTML] Genetic findings of potential donor origin following hematopoietic cell transplantation: recommendations on donor disclosure and genetic testing from the …

A Pryce, E Van Eerden, M Cody, J Oakes… - … and Cellular Therapy, 2024 - Elsevier
Following hematopoietic cell transplantation (HCT), recipients are subjected to extensive
genetic testing to monitor the efficacy of the transplantation and identify relapsing malignant …

Clinical considerations at the intersection of hematopoietic cell transplantation and hereditary hematopoietic malignancy

TE O'Connor, R Shaw, R Madero-Marroquin… - Frontiers in …, 2023 - frontiersin.org
In recent years, advances in genetics and the integration of clinical-grade next-generation
sequencing (NGS) assays into patient care have facilitated broader recognition of hereditary …

Donor derived leukemia in allogeneic transplantation

I Aldoss, M Clark, G Marcucci, SJ Forman - Leukemia & Lymphoma, 2021 - Taylor & Francis
Allogeneic hematopoietic cell transplantation (alloHCT) is a curative option for the treatment
of eligible patients with hematological malignancies. This modality confers a risk for life …

Donor cell-derived genetic abnormalities after sex mismatched allogeneic cell transplantation: a unique challenge of donor cell leukemia

M Klausner, B Phan, L Morsberger, R Parish… - Blood cancer …, 2023 - nature.com
Dear Editor, Allogeneic hematopoietic cell transplantation (alloHCT) is an important and
curative therapeutic approach for patients with hematological malignancies. Given the …

Germline assessment for alloHSCT candidates over 50 years: A 'Fast‐Track'screening in myeloid neoplasms

S Torres‐Esquius, F Beas… - British Journal of …, 2024 - Wiley Online Library
Patients aged 50 or above diagnosed with myeloid neoplasms (MNs) are typically not
candidates for germline testing. However, approximately 8% carry pathogenic germline …

Hypothesis: can transfer of primary neoplasm-derived extracellular vesicles and mitochondria contribute to the development of donor cell–derived hematologic …

M Imamura - Cytotherapy, 2022 - Elsevier
Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential treatment option for
various neoplastic and non-neoplastic hematologic diseases. Although its efficacy is …

Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation

L Nevejan, F Nollet, H Devos, M Vynck… - Blood …, 2020 - ashpublications.org
The recent study of Boettcher et al1 describes 5 cases of donor-engrafted clonal
hematopoiesis (CH), one of which progressed into myelodysplastic syndrome (MDS) in both …