The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising
enzymes, having the greatest effects on the expression of cytochrome P450 (CYP) 3A4 in …

The pregnane X receptor (PXR, NR1I2) is a ligand activated transcription factor that belongs
to the nuclear hormone receptor (NR) superfamily. PXR is highly expressed in the liver and …

The increasing emergence of antimicrobial-resistant organisms, especially methicillin-
resistant Staphylococcus aureus (MRSA), has resulted in the increased use of rifampin …

Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes. A few examples of
well-documented clinically significant interactions include interactions with warfarin, oral …

Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome
P450 (CYP) isoforms to a stable metabolite, EDDP. Methadone is a chiral drug administered …

CYP3A activity in adults varies between individuals and it has been suggested that this has
a genetic basis, possibly related to variant alleles in CYP3A4 and CYP3A5 genes …

HepaRG is a highly differentiated cell line that displays several hepatocyte-like functions,
including drug-metabolizing enzymes. In this study, the HepaRG cells were characterized …

Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor
superfamily, regulates the expression of metabolic enzymes and transporters involved in the …

Cytochrome P450 3A4 (CYP3A4), an enzyme that is highly expressed in the human liver
and small intestine, plays a major role in the metabolism of a large variety of xenobiotics …

HIV-infected individuals usually receive a wide variety of drugs in addition to their
antiretroviral drug regimen. Since both non-nucleoside reverse transcriptase inhibitors and …