Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Developing a more comprehensive understanding of the physiological underpinnings of
mental illness, precision medicine has the potential to revolutionize psychiatric care. With …

Major depressive disorder (MDD) is a disease associated with many factors; specifically,
environmental, genetic, psychological, and biological factors play critical roles. Recent …

Converging clinical and preclinical evidence demonstrates that depressive phenotypes are
associated with synaptic dysfunction and dendritic simplification in cortico-limbic …

Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans
in recent years, whereas its genetic basis in other populations remains relatively less …

Several lines of evidence support the involvement of transcriptomic and epigenetic
mechanisms in the brain structural deficits of major depressive disorder (MDD) separately …

Neuroinflammation is associated with the development of depression. Deacetylases SIRT1
and SIRT2 are reported to exert neuroprotective effects in aging, neurogenesis …

Genome-wide association studies (GWAS) of major depression and its relevant biological
phenotypes have been extensively conducted in large samples, and transcriptome-wide …

Recent advances in functional genomics have facilitated the identification of multiple genes
and isoforms associated with the genetic risk of schizophrenia, yet the causal variations …