Targeting cancer stem cell pathways for cancer therapy

L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

PPARs and tumor microenvironment: the emerging roles of the metabolic master regulators in tumor stromal–epithelial crosstalk and carcinogenesis

HS Cheng, YS Yip, EKY Lim, W Wahli, NS Tan - Cancers, 2021 - mdpi.com
Simple Summary The roles of peroxisome proliferator-activated receptors (PPARs) in
carcinogenesis are increasingly appreciated. With the growing interest in tumor stromal …

Molecular iodine has extrathyroidal effects as an antioxidant, differentiator, and immunomodulator

C Aceves, I Mendieta, B Anguiano… - International journal of …, 2021 - mdpi.com
Most investigations of iodine metabolism in humans and animals have focused on its role in
thyroid function. However, considerable evidence indicates that iodine could also be …

Pterostilbene suppresses both cancer cells and cancer stem-like cells in cervical cancer with superior bioavailability to resveratrol

HJ Shin, JM Han, YS Choi, HJ Jung - Molecules, 2020 - mdpi.com
Increasing studies have reported that cancer stem cells (CSCs) play critical roles in
therapeutic resistance, recurrence, and metastasis of tumors, including cervical cancer …

Signaling pathways in the regulation of cancer stem cells and associated targeted therapy

W Manni, W Min - MedComm, 2022 - Wiley Online Library
Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with
selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into …

[HTML][HTML] Cancer stem cell impact on clinical oncology

ME Toledo-Guzmán, GD Bigoni-Ordóñez… - World journal of stem …, 2018 - ncbi.nlm.nih.gov
Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate
from cancer correlates with a lack of clear symptoms, which results in late diagnosis for …

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

J Sun, L Yu, X Qu, T Huang - Frontiers in Pharmacology, 2023 - frontiersin.org
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over
3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally …

Targeting cervical cancer stem cells by phytochemicals

T Tripathi, J Yadav, D Janjua… - Current Medicinal …, 2024 - benthamdirect.com
Cervical cancer (CaCx) poses a significant global health challenge, ranking as the fourth
most common cancer among women worldwide. Despite the emergence of advanced …

Synthesis and characterization of iodinated chitosan nanoparticles and their effects on cancer cells

G Alvarado Tenorio, R Espinosa Neira… - International Journal …, 2024 - Wiley Online Library
The high degree of chemical modification of the chitosan chains due to protonated amine
groups allows them to react with many negatively charged surfaces as anionic polymers and …