[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
Coronavirus belongs to the family of Coronaviridae, comprising single-stranded, positive-
sense RNA genome (+ ssRNA) of around 26 to 32 kilobases, and has been known to cause …

The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation

Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …

The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China

Y Yang, F Peng, R Wang, K Guan, T Jiang, G Xu… - Journal of …, 2020 - Elsevier
The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This
viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those …

Emerging coronaviruses: genome structure, replication, and pathogenesis

Y Chen, Q Liu, D Guo - Journal of medical virology, 2020 - Wiley Online Library
The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of
unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of …

[PDF][PDF] SARS-CoV-2, SARS-CoV, and MERS-COV: a comparative overview

AA Rabaan, SH Al-Ahmed, S Haque, R Sah, R Tiwari… - Infez Med, 2020 - infezmed.it
SUMMARY and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is
very similar in structure and pathogenicity with SARS-CoV, but the most important structural …

[PDF][PDF] Properties of coronavirus and SARS-CoV-2

YA Malik - The Malaysian journal of pathology, 2020 - mjpath.org.my
Zoonotic coronaviruses were discovered in the 1960s. Since then pathogenic human
coronaviruses were identified beginning with the discovery of SARS-CoV in 2002. With the …

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

S Lu, Q Ye, D Singh, Y Cao, JK Diedrich… - Nature …, 2021 - nature.com
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …

Evaluation of nucleocapsid and spike protein-based enzyme-linked immunosorbent assays for detecting antibodies against SARS-CoV-2

W Liu, L Liu, G Kou, Y Zheng, Y Ding, W Ni… - Journal of clinical …, 2020 - Am Soc Microbiol
At present, PCR-based nucleic acid detection cannot meet the demands for coronavirus
infectious disease (COVID-19) diagnosis. Two hundred fourteen confirmed COVID-19 …

From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

N Kirtipal, S Bharadwaj, SG Kang - Infection, Genetics and Evolution, 2020 - Elsevier
Abstract Human Coronaviruses (HCoV), periodically emerging across the world, are
potential threat to humans such as severe acute respiratory syndrome coronavirus-2 (SARS …

Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks

HM Ashour, WF Elkhatib, MM Rahman, HA Elshabrawy - Pathogens, 2020 - mdpi.com
Coronaviruses (CoVs) are RNA viruses that have become a major public health concern
since the Severe Acute Respiratory Syndrome-CoV (SARS-CoV) outbreak in 2002. The …