Phenylketonuria (PKU; also known as phenylalanine hydroxylase (PAH) deficiency) is an
autosomal recessive disorder of phenylalanine metabolism, in which especially high …

Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …

More than 950 phenylalanine hydroxylase (PAH) gene variants have been identified in
people with phenylketonuria (PKU). These vary in their consequences for the residual level …

Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug
concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded …

Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes
which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or …

Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing
to their innate homing/targeting abilities. Here, we review molecular interactions involved in …

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly
developing field. Such erythrocytes can act as carriers that prolong the drug's action due to …

In the past five decades, red blood cells (RBCs) have been extensively explored as drug
delivery systems due to their distinguishing potential in modulating the pharmacokinetic …

Radiotherapy (IR) is capable of enhancing antitumor immune responses. However, IR
treatment also aggravates the infiltration of peripheral macrophages into the tumor, resulting …

Acute pneumonia is an inflammatory syndrome often associated with severe multi-organ
dysfunction and high mortality. The therapeutic efficacy of current anti-inflammatory …